MUTAGENICITY TESTS OF ETOPOSIDE AND TENIPOSIDE
نویسندگان
چکیده
منابع مشابه
DNA Topoisomerase II«Gene Expression under Transcriptional Control in Etoposide/Teniposide-resistant Human Cancer Cells1
We previously isolated etoposide/teniposide-resistant cell lines from human cancer KB cells, designated KB/VP-2 and KB/VM-4, respectively, and we found that decreased expression of topoisomerase Ha was asso ciated with the acquisition of etoposide/teniposide resistance in both re sistant cell lines. In this study, we studied how the expression of the DNA topoisomerase Ila gene is regulated in d...
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15 صفحه اولAltered formation of DNA in human cells treated with inhibitors of DNA topoisomerase II (etoposide and teniposide).
We have investigated the importance of DNA topoisomerase II for the formation of mammalian DNA replication intermediates. Treatment with the DNA topoisomerase II inhibitor etoposide (teniposide) prevents the formation of large intermediates, such as 10-kilobase DNA, but allows the formation of small intermediates, i.e., Okazaki fragments. In untreated cells, there is a distinct stage in which t...
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Dexrazoxane (ICRF-187) is a catalytic inhibitor of the nuclear enzyme DNA topoisomerase II (topo II). It protects cells against topo II poisons, such as etoposide and teniposide, by hindering the DNA cleavage reaction of the target enzyme. We have previously shown that this antagonism also extends to an in vivo model. Thus, ICRF-187 protected mice against supralethal doses of etoposide and amsa...
متن کاملMechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines.
Stable acquired resistance to etoposide (VP-16) or teniposide (VM-26) in HCT116 human colon carcinoma cells and A549 human lung adenocarcinoma cells, was previously obtained by weekly 1-h exposures to either drug (B. H. Long, Natl. Cancer Inst. Monogr., 4: 123-127, 1987). The purpose of this study was to identify possible mechanisms of resistance present in these cells by using human mdr1 and t...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1986
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.11.supplementi_301